Doctors have noticed that the impotence drug Viagra can cause aggressive behavior and sexual violence. In July, Dr. Harold A. Milman published an article in the Annals of Pharmacotherapy about more than 12,000 reports of violence in men who took Viagra. The drug was listed as the possible cause of 13 rapes and 6 murders.

The theory that the drug can cause aggression is basis of the “Viagra defense,” a claim made by 6 defendants since 1998 that the drug caused them to commit violent crimes. Milman was hired as an expert witness in one of the cases. The Viagra defense hasn?t gotten any defendants off so far.

Other scientists say Viagra couldn?t be the culprit, because it causes erections by working directly on the blood vessels of the penis, not through the brain. “You could take any product and connect individuals who use it with certain behaviors. I think it’s a coincidence,” says Geoff Cook, of Pfizer, the manufacturer of the drug. But Milman has found research showing that Viagra can enter the brain and affect biological pathways in the parts that control aggression.

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